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Showing 1–2 of 2 results
Advanced filters: Author: Laure Guitton-Sert Clear advanced filters

  • Formaldehyde can trigger formation of interstrand crosslinks (ICLs) or DNA-protein crosslinks (DPCs) leading to genome instability. Here the authors show that EXO1 limits replication stress and DNA damage to counteract formaldehyde-induced genome instability.

    • Yuandi Gao
    • Laure Guitton-Sert
    • Jean-Yves Masson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • DNA polymerase θ (Pol θ) exhibits properties typical of translesion and repair synthesis; however, its physiological function remains elusive. Here, the authors show that Pol θ plays a role in the initiation and timing of DNA replication during human cell division.

    • Anne Fernandez-Vidal
    • Laure Guitton-Sert
    • Jean-Sébastien Hoffmann
    Research
    Nature Communications
    Volume: 5, P: 1-10