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Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

The cell-intrinsic pathways controlling the function of innate lymphoid cells are poorly defined. Artis and colleagues demonstrate that ILC2s selectively express arginase 1 and that this is critical for their bioenergetics, proliferation and function.

Laurel A Monticelli
Michael D Buck
David Artis
Research04 Apr 2016
Nature Immunology

Volume: 17, P: 656-665
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

Cytokine-producing innate lymphoid cells are found at mucosal surfaces. Artis and Wherry and their colleagues show that innate 'nuocyte-like' cells accumulate in virus-infected lungs and contribute to the repair of tissues.

Laurel A Monticelli
Gregory F Sonnenberg
David Artis
Research25 Sept 2011
Nature Immunology

Volume: 12, P: 1045-1054
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

Group 2 innate lymphoid cells are shown to have a critical role in energy homeostasis by producing methionine-enkephalin peptides in response to interleukin 33, thus promoting the beiging of white adipose tissue; increased numbers of beige (also known as brown-like or brite) fat cells in white adipose tissue leads to increased energy expenditure and decreased adiposity.

Jonathan R. Brestoff
Brian S. Kim
David Artis
Research22 Dec 2014
Nature

Volume: 519, P: 242-246
Innate lymphoid cells regulate CD4⁺ T-cell responses to intestinal commensal bacteria

Group 3 innate lymphoid cells are shown to process and present antigen and to control CD4⁺ T-cell responses to intestinal commensal bacteria through an MHC-class-II-dependent mechanism.

Matthew R. Hepworth
Laurel A. Monticelli
Gregory F. Sonnenberg
Research22 May 2013
Nature

Volume: 498, P: 113-117
The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

Intestinal type 2 innate lymphoid cells express the neuropeptide receptor NMUR1, which makes them responsive to neuronal neuromedin U, thereby promoting a type 2 cytokine response and accelerated expulsion of the gastro-intestinal nematode Nippostrongylus brasiliensis.

Christoph S. N. Klose
Tanel Mahlakõiv
David Artis
Research06 Sept 2017
Nature

Volume: 549, P: 282-286
Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice

Barbara D. Summers
Kihwan Kim
Hasina Outtz Reed
ResearchOpen Access23 Mar 2022
Scientific Reports

Volume: 12, P: 1-14

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Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice

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Innate lymphoid cells regulate CD4⁺ T-cell responses to intestinal commensal bacteria