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Showing 1–4 of 4 results
Advanced filters: Author: Lauren A. Choate Clear advanced filters

  • A new study tracks the distribution of bivalent H3K4me3/H3K27me3 chromatin in male germ cells of six vertebrate species. The results have big implications for understanding the mechanisms that specify animal development.

    • Lauren A Choate
    • Charles G Danko
    News & Views
    Nature Genetics
    Volume: 48, P: 822-823

  • Animal husbandry and hunting has increased human exposure to pathogens. Here, the authors investigate the evolution of human host gene expression to Bacillus anthracis infection, the bacterium that causes anthrax disease. They observe recent positive selection, suggestive of human genome adaptation to anthrax disease.

    • Lauren A. Choate
    • Gilad Barshad
    • Charles G. Danko
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • It is unclear how evolutionary changes at enhancers affect the transcription of target genes. Measuring nascent transcription in CD4+ T cells in primates, the authors show that the effects of evolutionary changes in enhancers are buffered at the transcriptional level.

    • Charles G. Danko
    • Lauren A. Choate
    • Adam Siepel
    Research
    Nature Ecology & Evolution
    Volume: 2, P: 537-548