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Showing 1–6 of 6 results
Advanced filters: Author: Lauren S. Koepke Clear advanced filters

  • How bone-related sexually dimorphic traits are regulated hasn’t been examined at the stem cell level. Here the authors show that skeletal stem cells (SSC), in female but not male mice, are directly controlled by estrogen signaling, which could be augmented to improve fracture repair.

    • Tom W. Andrew
    • Lauren S. Koepke
    • Charles K. F. Chan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • An analysis of skeletal stem cells in mice reveals that bone ageing occurs at the level of local niches affecting skeletal and haematopoietic lineage output, which may influence systemic aspects of multi-organ physiological ageing.

    • Thomas H. Ambrosi
    • Owen Marecic
    • Charles K. F. Chan
    Research
    Nature
    Volume: 597, P: 256-262

  • The authors present a FACS-based protocol for the purification of human skeletal stem cell lineages from a variety of tissue sources, alongside in vitro and in vivo skeletogenic functional assays, human xenograft mouse models and single-cell RNA sequencing analysis.

    • Malachia Y. Hoover
    • Thomas H. Ambrosi
    • Charles K. F. Chan
    Protocols
    Nature Protocols
    Volume: 18, P: 2256-2282

  • Endogenous skeletal stem cells are recruited to form cartilage in mice when stimulated by microfracture surgery together with localized delivery of growth factors, pointing to a new approach for treating cartilage defects.

    • Matthew P. Murphy
    • Lauren S. Koepke
    • Charles K. F. Chan
    Research
    Nature Medicine
    Volume: 26, P: 1583-1592

  • A flow cytometry–based approach using eight surface markers is used to distinguish cells of the skeletal stem cell lineage. Renal subcapsular transplantation and in vitro colony-formation assays are also described for cell characterization.

    • Gunsagar S Gulati
    • Matthew P Murphy
    • Charles K F Chan
    Protocols
    Nature Protocols
    Volume: 13, P: 1294-1309