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Showing 1–10 of 10 results
Advanced filters: Author: Laurence Aitchison Clear advanced filters

  • Analysing gut microbial time series from wild baboons, the authors show that microbiome dynamics are rarely synchronized across hosts in shared environments but are highly individualized even within the same social groups.

    • Johannes R. Björk
    • Mauna R. Dasari
    • Elizabeth A. Archie
    Research
    Nature Ecology & Evolution
    Volume: 6, P: 955-964

  • Secretory IgA plays vital roles interfacing between the host immune system and the resident microbiota at the mucosal surface. Here the authors explore the effect of dietary protein on the production of secretory IgA, driven by the production of extracellular vesicles by the intestinal microbiota.

    • Jian Tan
    • Duan Ni
    • Laurence Macia
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • A prospective analysis of gut microbiome signatures in patients treated with neoadjuvant immunocheckpoint blockade for high risk resectable metastatic melanoma identifies new links between microbiota signatures, dietary intake and systemic inflammation in shaping the response and toxicity to immunotherapy.

    • Rebecca C. Simpson
    • Erin R. Shanahan
    • Georgina V. Long
    Research
    Nature Medicine
    Volume: 28, P: 2344-2352

  • We propose that synapses compute probability distributions over weights, not just point estimates. Using probabilistic inference, we derive a new set of synaptic learning rules and show that they speed up learning in neural networks.

    • Laurence Aitchison
    • Jannes Jegminat
    • Peter E. Latham
    Research
    Nature Neuroscience
    Volume: 24, P: 565-571

  • European governments control resurging waves of COVID-19 using nonpharmaceutical interventions. Here, the authors estimate the effectiveness of 17 interventions in Europe’s second wave, and analyse differences to the first wave as well as implications for the future of the pandemic.

    • Mrinank Sharma
    • Sören Mindermann
    • Jan Markus Brauner
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • VVD-133214, a clinical-stage, covalent allosteric inhibitor of the helicase WRN, was well tolerated in mice and led to robust tumour regression in multiple microsatellite-instability-high colorectal cancer cell lines and patient-derived xenograft models.

    • Kristen A. Baltgalvis
    • Kelsey N. Lamb
    • Todd M. Kinsella
    Research
    Nature
    Volume: 629, P: 435-442

  • Combining electrophysiology and computational modeling, the authors show that the dendrites of entorhinal cortex stellate and pyramidal cells are electrically excitable and that this improves the robustness of grid cell firing. The results suggest that active dendrites are critical for spatial navigation, a fundamental computation in the brain.

    • Christoph Schmidt-Hieber
    • Gabija Toleikyte
    • Michael Häusser
    Research
    Nature Neuroscience
    Volume: 20, P: 1114-1121

  • Bang et al. use behavioural data in culturally distinct settings (United Kingdom and Iran) and computational modelling to show that, when making decisions in pairs, people adopt a confidence-matching heuristic to combine their opinions.

    • Dan Bang
    • Laurence Aitchison
    • Christopher Summerfield
    Research
    Nature Human Behaviour
    Volume: 1, P: 1-7