Nature Search

Understanding the limits to generalizability of experimental evolutionary models

This paper reports the construction of mathematical models for how host-parasite co-evolution might affect diversity at different nutrient levels. Using the example of T7 phage and Escherichia coli, it was shown that many results are insensitive to the biological details of the interaction, but peculiarities of the model system can be predicted and experimentally verified.

Samantha E. Forde
Robert E. Beardmore
Laurence D. Hurst
Research11 Sept 2008
Nature

Volume: 455, P: 220-223
A RCT for assessment of active human-centred learning finds teacher-centric non-human teaching of evolution optimal

Loredana Buchan
Momna Hejmadi
Laurence D. Hurst
ResearchOpen Access04 Dec 2020
npj Science of Learning

Volume: 5, P: 1-20
A century of bias in genetics and evolution

Laurence D. Hurst
Reviews12 Jun 2019
Heredity

Volume: 123, P: 33-43
The evolution of isochores

Adam Eyre-Walker
Laurence D. Hurst
Reviews01 Jul 2001
Nature Reviews Genetics

Volume: 2, P: 549-555
Genetics and the understanding of selection

Looking back over the relationship between natural selection and genetics highlights the important role of genetics in understanding the implications of Darwin's concept. Looking to the future, understanding the reach and role of selection also has profound implications for genetics.

Laurence D. Hurst
Reviews01 Feb 2009
Nature Reviews Genetics

Volume: 10, P: 83-93
Sex and the X

Are genomes made up of strings of genes in no particular order? It seems not, given the abundance on the mouse sex chromosomes of genes involved in the manufacture of sperm.

Laurence D. Hurst
News & Views10 May 2001
Nature

Volume: 411, P: 149-150
Identification of Two Maternal Transmission Ratio Distortion Loci in Pedigrees of the Framingham Heart Study

Yang Liu
Liangliang Zhang
Xiangyin Kong
ResearchOpen Access05 Jul 2013
Scientific Reports

Volume: 3, P: 1-5
Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias

GC-biased gene conversion has many implications for evolutionary genetics, but its prevalence is unknown. Here, direct sequencing of tetrads in four species shows large differences in gene-conversion rate but no evidence of overall GC bias.

Haoxuan Liu
Ju Huang
Sihai Yang
Research20 Nov 2017
Nature Ecology & Evolution

Volume: 2, P: 164-173
Peromysci, promiscuity and imprinting

Laurence D Hurst
News & Views01 Dec 1998
Nature Genetics

Volume: 20, P: 315-316
Mystery of the mutagenic male

Old fathers are the source of more genetic mutations in their offspring than either young fathers or mothers of any age. But the apparently most plausible explanation for this effect might not hold.

Laurence D. Hurst
Hans Ellegren
News & Views28 Nov 2002
Nature

Volume: 420, P: 365-366
Dissecting dispensability

Like most organisms, yeast has relatively few genes that are necessary for viability. The presence of a duplicate gene elsewhere in the genome underpins many cases of dispensability. A new study suggests that the backup mechanism is more complex than previously assumed and requires feedback loops that ensure transcriptional upregulation of the duplicate.

Laurence D Hurst
Csaba Pál
News & Views01 Mar 2005
Nature Genetics

Volume: 37, P: 214-215
The eyes have it

Females of many species prefer mates with extravagant traits. Studies of stalk-eyed flies show that, in this case at least, such preference is linked to suppression of a selfish gene that influences the sex ratio of offspring.

Laurence D. Hurst
Andrew Pomiankowski
News & Views15 Jan 1998
Nature

Volume: 391, P: 223-224
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with macrocephaly and speech and language impairment.

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Book reviews

Laurence D Hurst
Books & Arts01 Aug 1996
Heredity

Volume: 77, P: 228-229
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

An extensive analysis of HERVH (a primate-specific endogenous retrovirus) expression in human pluripotent stem cells is presented, identifying a sub-population of cells within cultured human embryonic stem cells and induced pluripotent stem cells that has characteristics of naive-state cells — the study provides evidence for a new primate-specific transcriptional circuitry regulating pluripotency.

Jichang Wang
Gangcai Xie
Zsuzsanna Izsvák
Research15 Oct 2014
Nature

Volume: 516, P: 405-409
Open questions in the study of de novo genes: what, how and why

In this Opinion article, the authors discuss important questions relating to the study ofde novo genes. They discuss the challenges of identifying de novogenes, understanding how they originate and why they spread, and propose that antagonistic evolution may have a key role in their evolution.

Aoife McLysaght
Laurence D. Hurst
Reviews25 Jul 2016
Nature Reviews Genetics

Volume: 17, P: 567-578
Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

Genetic imprinting, or the preferential expression of a single parental allele, has typically been implicated as an influential factor during development, but whether unequal representation of one allele can influence social behaviour has not been studied. Here, it is demonstrated that the adaptor protein Grb10 is predominantly expressed from the paternal allele in brain and that ablating this allelic bias induces behavioural modifications of a social nature. At this time, Grb10 is unique in the sense that tissue-specific actions of each parental allele can influence distinct physiological or behavioural processes.

Alastair S. Garfield
Michael Cowley
Andrew Ward
Research26 Jan 2011
Nature

Volume: 469, P: 534-538
X-chromosome meiotic drive in Drosophila simulans: a QTL approach reveals the complex polygenic determinism of Paris drive suppression

Cécile Courret
Pierre R. Gérard
Catherine Montchamp-Moreau
Research05 Dec 2018
Heredity

Volume: 122, P: 906-915
Selection on synonymous sites: the unwanted transcript hypothesis

Multiple mechanisms have evolved to prevent or trap deleterious unwanted transcripts. The unwanted transcript hypothesis proposes that selection at synonymous sites favours mutations that prevent the generation of unwanted transcripts or that make native transcripts appear ‘wanted’ by being GC-rich.

Sofia Radrizzani
Grzegorz Kudla
Laurence D. Hurst
Reviews31 Jan 2024
Nature Reviews Genetics

Volume: 25, P: 431-448
The evolution of gene number: are heritable and non-heritable errors equally important?

Csaba Pál
Laurence D Hurst
Reviews01 Apr 2000
Heredity

Volume: 84, P: 393-400
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access02 May 2019
Nature Communications

Volume: 10, P: 1-4
BCL11A intellectual developmental disorder: defining the clinical spectrum and genotype-phenotype correlations

Angela Peron
Felice D’Arco
Cristina Dias
ResearchOpen Access24 Oct 2024
European Journal of Human Genetics

Volume: 33, P: 312-324
Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

This protocol describes how to genetically and phenotypically tag, select and maintain naive-like hPSCs to enable homogenous hPSC cultures to be derived, characterized and maintained over the long term.

Jichang Wang
Manvendra Singh
Zsuzsanna Izsvák
Protocols21 Jan 2016
Nature Protocols

Volume: 11, P: 327-346
Exome sequencing identifies frequent mutation of MLL2 in non–small cell lung carcinoma from Chinese patients

Shanye Yin
Jing Yang
Xiangyin Kong
ResearchOpen Access12 Aug 2014
Scientific Reports

Volume: 4, P: 1-7
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

Tobias Schwerd
Freia Krause
Holm H. Uhlig
ResearchOpen Access11 Jun 2020
Bone Research

Volume: 8, P: 1-12
Epistasis and the Evolutionary Process

Laurence D Hurst
Books & Arts01 Dec 2000
Heredity

Volume: 85, P: 625-626

Search

Understanding the limits to generalizability of experimental evolutionary models

A RCT for assessment of active human-centred learning finds teacher-centric non-human teaching of evolution optimal

A century of bias in genetics and evolution

The evolution of isochores

Genetics and the understanding of selection

Sex and the X

Identification of Two Maternal Transmission Ratio Distortion Loci in Pedigrees of the Framingham Heart Study

Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias

Peromysci, promiscuity and imprinting

Mystery of the mutagenic male

Dissecting dispensability

The eyes have it

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Book reviews

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

Open questions in the study of de novo genes: what, how and why

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

X-chromosome meiotic drive in Drosophila simulans: a QTL approach reveals the complex polygenic determinism of Paris drive suppression

Selection on synonymous sites: the unwanted transcript hypothesis

The evolution of gene number: are heritable and non-heritable errors equally important?

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

BCL11A intellectual developmental disorder: defining the clinical spectrum and genotype-phenotype correlations

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

Exome sequencing identifies frequent mutation of MLL2 in non–small cell lung carcinoma from Chinese patients

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

Epistasis and the Evolutionary Process

Search

Quick links

Search

Filter By:

Search

Quick links