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Showing 1–7 of 7 results

Advanced filters: Author: Laurent Coudert Clear advanced filters

Delivery of Prime editing in human stem cells using pseudoviral NanoScribes particles

Prime Editing is an advanced CRISPRCas9-based tool for precisely rewriting genes in living cells. Here, authors designed virus-like particles optimized to safely and efficiently introduce this technology into human cells of therapeutic interest.

Thibaut Halegua
Valérie Risson
Philippe Emmanuel Mangeot
ResearchOpen Access04 Jan 2025
Nature Communications

Volume: 16, P: 1-12
Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments

DNA damage causes a major reorganization of the nucleolus. Here, the authors find that this structural restoration depends on the shuttling of the protein SMN from the Cajal bodies to the nucleolus, which requires coilin and PRMT1.

Shaqraa Musawi
Lise-Marie Donnio
Giuseppina Giglia-Mari
ResearchOpen Access15 Nov 2023
Nature Communications

Volume: 14, P: 1-17
Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation

Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.

Alexis Osseni
Aymeric Ravel-Chapuis
Laurent Schaeffer
ResearchOpen Access19 Nov 2022
Nature Communications

Volume: 13, P: 1-16
Formation of the methyl cation by photochemistry in a protoplanetary disk

JWST observations of CH₃⁺ in a protoplanetary disk in the Orion star-forming region are reported showing that gas-phase organic chemistry in the interstellar medium is activated by ultraviolet irradiation and the methyl cation.

Olivier Berné
Marie-Aline Martin-Drumel
Mark G. Wolfire
Research26 Jun 2023
Nature

Volume: 621, P: 56-59
Exploring the genetic landscape of HCV-related B-cell lymphomas using whole exome sequencing

Marine Armand
Michaël Degaud
Lucile Couronné
Research13 Mar 2023
Leukemia

Volume: 37, P: 1388-1391
Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy

Jean-David Fumet
Corentin Richard
François Ghiringhelli
ResearchOpen Access15 Oct 2018
British Journal of Cancer

Volume: 119, P: 950-960
Correction: Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy

Jean-David Fumet
Corentin Richard
François Ghiringhelli
Amendments and CorrectionsOpen Access24 Jun 2019
British Journal of Cancer

Volume: 121, P: 283