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Showing 1–4 of 4 results
Advanced filters: Author: Laurent Derré Clear advanced filters

  • Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce myeloid-derived suppressor cells and support tumour growth.

    • Sara Trabanelli
    • Mathieu F. Chevalier
    • Camilla Jandus
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Epithelial ovarian cancer (EOC) has low mutational load. Here the authors analyze circulating and tumor-infiltrating lymphocytes (TILs) from 19 EOC patients and report frequent recovery of neo-antigen-reactive T cells from both compartments but with distinct TCR repertoires that have higher affinity in TILs.

    • Sara Bobisse
    • Raphael Genolet
    • Alexandre Harari
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Schneider et al. review the multifaceted immunoregulatory responses in the pathophysiology and treatment of bladder cancer, focusing on immune checkpoints and the various immune cells of the tumour microenvironment. They discuss alterations of these immune regulators, their clinical relevance and therapeutic targeting strategies.

    • Anna K. Schneider
    • Mathieu F. Chevalier
    • Laurent Derré
    Reviews
    Nature Reviews Urology
    Volume: 16, P: 613-630