Trinucleotide repeat expansions are linked to many diseases, and why there are differences in expansion rates according to tissue type or patient age is unclear. Now an analysis of replication patterns in patient fibroblasts and transgenic mouse tissues carrying the human DM1 locus reveals how changes in modes of replication origin activation around the repeat can lead to expansions.
- John D Cleary
- Stéphanie Tomé
- Christopher E Pearson
