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Showing 1–21 of 21 results
Advanced filters: Author: Laurent Gapin Clear advanced filters

  • Invariant natural killer T (iNKT) cells are thought to be autoreactive by 'design'. Here, Laurent Gapin describes how iNKT cell autoreactivity might be triggered and proposes that several self lipids are probably involved in the positive selection of iNKT cells and the autoreactivity of these cells in peripheral tissues.

    • Laurent Gapin
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 272-277

  • The growing impact of second-tier cities is narrowing the gap in research production.

    • Marion Maisonobe
    • Laurent Jégou
    • Guillaume Cabanac
    Special Features
    Nature
    Volume: 563, P: S18-S19

  • Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental regulation, with a transcription factor, Hivep3, implicated for the maturation of both cell types.

    • S. Harsha Krovi
    • Jingjing Zhang
    • Laurent Gapin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces epigenetic changes of genes to modulate iNKT lineages.

    • Kathryn D. Tuttle
    • S. Harsha Krovi
    • Laurent Gapin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Natural killer T cells acquire their unique phenotype and characteristics during development in the thymus. Evidence suggests that the transcription factor PLZF has a unique function in the development of these cells and their acquisition of 'innate-like' characteristics.

    • Laurent Gapin
    News & Views
    Nature Immunology
    Volume: 9, P: 1009-1011

  • The epigenetic regulation of gene expression by the histone demethylase UTX is central to the development of invariant natural killer cells.

    • S Harsha Krovi
    • Laurent Gapin
    News & Views
    Nature Immunology
    Volume: 18, P: 148-150

  • Natural killer T cells (NKT cells) recognize lipid antigens presented by CD1d. Zajonc and Rossjohn and their colleagues describe molecular interactions between type II NKT cell antigen receptors and CD1d-ligand complexes, which demonstrate distinct modes of recognition used by the receptors.

    • Onisha Patel
    • Daniel G Pellicci
    • Jamie Rossjohn
    Research
    Nature Immunology
    Volume: 13, P: 857-863

  • Germline-encoded mycolyl lipid-reactive (GEM) T cells recognize CD1b proteins presenting mycobacterial mycolates via their T-cell receptors (TCRs). Here, the authors present the structure of this interaction and provide a molecular basis for the co-recognition of CD1b and a mycobacterial glycolipid.

    • Stephanie Gras
    • Ildiko Van Rhijn
    • Jamie Rossjohn
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Here, the authors discuss how the T cell receptors expressed by natural killer T cells are able to recognize and respond to an array of self and foreign lipid antigens that are presented on CD1d molecules. They explain how a better understanding of these processes could be exploited for therapeutic purposes.

    • Jamie Rossjohn
    • Daniel G. Pellicci
    • Dale I. Godfrey
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 845-857

  • Here Ramanan and colleagues provide an analysis of mammary T cells during late pregnancy and lactation. This revealed an increase in intraepithelial lymphocytes in the lactating mammary gland, which was driven by thymic and intestinal inputs and was sensitive to changes in the microbiota

    • Abigail Jaquish
    • Eleni Phung
    • Deepshika Ramanan
    Research
    Nature Immunology
    Volume: 26, P: 1411-1422

  • T lymphocytes express clonal receptors, called T cell receptors (TCRs), which specifically recognize antigens presented in combination with major histocompatibility molecules (MHC). To date, T cell antigens can be broadly categorized into two classes: peptides and lipids. A recent paper published in Nature by Kjer-Nielsen and colleagues reveals that a unique population of T lymphocytes expresses TCRs that recognize a completely new and unexpected class of antigens, vitamin metabolites.

    • Mary H Young
    • Laurent Gapin
    Research Highlights
    Cell Research
    Volume: 23, P: 460-462