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Showing 1–2 of 2 results
Advanced filters: Author: Laurent Massotte Clear advanced filters

  • Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating downstream signaling.

    • Max Meyrath
    • Martyna Szpakowska
    • Andy Chevigné
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • A recent study suggests a novel role for the second extracellular loop of GPCRs: it may orchestrate a network of interactions that stabilize the inactive conformation of the receptor and control the on-off transition.

    • Dominique Massotte
    • Brigitte L Kieffer
    News & Views
    Nature Structural & Molecular Biology
    Volume: 12, P: 287-288