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Showing 1–2 of 2 results
Advanced filters: Author: Laurent Verkoczy Clear advanced filters

  • An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1 infected individual.

    • Wilton B. Williams
    • Jinsong Zhang
    • Laurent Verkoczy
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-20

  • Elucidation of broadly neutralizing antibodies (bnAb) is a goal in HIV vaccine development. Here, Bradley et al. show that administration of CTLA-4 blocking antibody with vaccine antigens increases HIV-1 envelope antibody responses in macaques and a bnAb precursor mouse model.

    • Todd Bradley
    • Masayuki Kuraoka
    • Barton F. Haynes
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16