The permeability of the intestinal epithelial barrier has a central role in the regulation of fluid and nutrient intake as well as in the control of the passage of pathogens. In this Review, Michel Neunlist and colleagues summarize current studies characterizing neuronal and glial effects on the intestinal epithelial barrier and outline the novel concept of a digestive neuronal–glial–epithelial unit.
- Michel Neunlist
- Laurianne Van Landeghem
- Malvyne Rolli-Derkinderen