Nature Search

Molecular correlates for HPV-negative head and neck cancer engraftment prognosticate patient outcomes

‘Engraftment of patient-derived xenografts in samples from head and neck squamous cell carcinoma is variable. Here, the authors use transcriptomic and proteomic profiling to correlate engraftment of PDX with molecular phenotype, and validate LAMC2 and TGM3 as potential biomarkers of stratification.

Matthew Waas
Christina Karamboulas
Thomas Kislinger
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-14
A role for Wnt signalling in self-renewal of haematopoietic stem cells

Tannishtha Reya
Andrew W. Duncan
Irving L. Weissman
Research27 Apr 2003
Nature

Volume: 423, P: 409-414
PRMT1 inhibition perturbs RNA metabolism and induces DNA damage in clear cell renal cell carcinoma

Here, the authors show that PRMT1 targeting inhibits clear cell renal cell carcinoma cells through perturbation of RNA metabolism and down-regulation of DNA repair pathways, resulting in the accumulation of unresolved R-loops and DNA damage.

Joseph Walton
Angel S. N. Ng
Laurie Ailles
ResearchOpen Access19 Sept 2024
Nature Communications

Volume: 15, P: 1-21
Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

Antonia Follenzi
Laurie E. Ailles
Luigi Naldini
Research01 Jun 2000
Nature Genetics

Volume: 25, P: 217-222
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Genome-wide CRISPR screens in mouse cancer cell lines are used to identify a core, conserved set of genes and pathways that govern how cancer cells evade killing by cytotoxic T lymphocytes.

Keith A. Lawson
Cristovão M. Sousa
Jason Moffat
Research23 Sept 2020
Nature

Volume: 586, P: 120-126
Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis

Extracellular matrix (ECM) homeostasis is essential for normal tissue function, and its perturbation by injury, trauma or disease results in fibrosis. Here, the authors show that glycolysis and the fatty acid oxidation pathway regulate fibroblast behaviour and have reciprocal effects in ECM upregulation and downregulation, respectively.

Xiao Zhao
Pamela Psarianos
Fei-Fei Liu
Research07 Jan 2019
Nature Metabolism

Volume: 1, P: 147-157
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

Khokha and colleagues report that loss of the Timp family of metalloproteinases from stromal fibroblasts promotes a cancer-associated fibroblast phenotype and production of exosomes that stimulate cancer cell motility.

Masayuki Shimoda
Simona Principe
Rama Khokha
Research24 Aug 2014
Nature Cell Biology

Volume: 16, P: 889-901
PBRM1, SETD2 and BAP1 — the trinity of 3p in clear cell renal cell carcinoma

In this Perspective, the authors provide an overview of the roles of three genes, PBRM1, SETD2 and BAP1, which are commonly lost with chromosome 3p deletion in patients with clear cell renal cell carcinoma (ccRCC). The authors discuss the implication of these genes in cancer-related pathways and how an improved understanding of these mechanisms might help to develop potential new therapies in ccRCC.

Joseph Walton
Keith Lawson
Laurie Ailles
Reviews17 Oct 2022
Nature Reviews Urology

Volume: 20, P: 96-115
Association of reactive oxygen species levels and radioresistance in cancer stem cells

This study shows that cancer stem cell in breast tumours have lower levels of reactive oxygen species (ROS) than the rest of the tumour cells. This property renders cancer stem cells less sensitive to radiation therapy, which may cause radioresistance in breast cancer.

Maximilian Diehn
Robert W. Cho
Michael F. Clarke
Research09 Apr 2009
Nature

Volume: 458, P: 780-783
The cancer stem cell hypothesis: a work in progress

Brenton Thomas Tan
Christopher Yongchul Park
Irving L Weissman
Research30 Oct 2006
Laboratory Investigation

Volume: 86, P: 1203-1207
Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas

Nada Jabado, Jacek Majewski and colleagues identify mutations in multiple histone H3 genes causing recurrent p.Lys36Met alterations in head and neck squamous cell carcinomas. They show that tumors with these p.Lys36Met alterations correspond to a specific DNA methylation cluster along with tumors harboring previously described mutations in NSD1.

Simon Papillon-Cavanagh
Chao Lu
Nada Jabado
Research09 Jan 2017
Nature Genetics

Volume: 49, P: 180-185
Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa

Laudine Communal
Mauricio Medrano
Anne-Marie Mes-Masson
Research08 Jun 2020
Modern Pathology

Volume: 33, P: 2361-2377
Cancer stem cells are underestimated by standard experimental methods in clear cell renal cell carcinoma

Craig Gedye
Danylo Sirskyj
Laurie E. Ailles
ResearchOpen Access28 Apr 2016
Scientific Reports

Volume: 6, P: 1-13
Primary esophageal and gastro-esophageal junction cancer xenograft models: clinicopathological features and engraftment

Lorin Dodbiba
Jennifer Teichman
Geoffrey Liu
Research11 Feb 2013
Laboratory Investigation

Volume: 93, P: 397-407

Search

Molecular correlates for HPV-negative head and neck cancer engraftment prognosticate patient outcomes

A role for Wnt signalling in self-renewal of haematopoietic stem cells

PRMT1 inhibition perturbs RNA metabolism and induces DNA damage in clear cell renal cell carcinoma

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

PBRM1, SETD2 and BAP1 — the trinity of 3p in clear cell renal cell carcinoma

Association of reactive oxygen species levels and radioresistance in cancer stem cells

The cancer stem cell hypothesis: a work in progress

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas

Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa

Cancer stem cells are underestimated by standard experimental methods in clear cell renal cell carcinoma

Primary esophageal and gastro-esophageal junction cancer xenograft models: clinicopathological features and engraftment

Search

Quick links

Search

Filter By:

Search

Quick links