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Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

A comprehensive analysis of models of brain metastasis and multiple cohorts of patient samples identifies a targetable molecular mechanism underlying the resistance to whole-brain radiotherapy that can inform patient selection for personalized radiotherapy.

Cátia Monteiro
Lauritz Miarka
Manuel Valiente
ResearchOpen Access11 Apr 2022
Nature Medicine

Volume: 28, P: 752-765

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Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

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