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Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study

Allergen specific immunotherapy (AIT) is both, safe and effective in reducing systemic symptoms of venom allergy in individuals. Here the authors examine the underlying immune cell changes after venom specific AIT in early time points after therapy initiation showing indicative changes in specific immune cell populations.

Dimitrii Pogorelov
Sebastian Felix Nepomuk Bode
Markus Ollert
ResearchOpen Access26 Nov 2024
Nature Communications

Volume: 15, P: 1-22
DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

Using in situ single cell lineage tracing technology DRAG, we show that, unlike emergency myelopoiesis post-transplantation, aged HSPCs do not functionally decline in the number of myeloid cells that they produce.

Jos Urbanus
Jason Cosgrove
Leïla Perié
ResearchOpen Access17 Apr 2023
Nature Communications

Volume: 14, P: 1-14
Residual ANTXR1+ myofibroblasts after chemotherapy inhibit anti-tumor immunity via YAP1 signaling pathway

An important contribution of cancer associated fibroblasts (CAFs) in regulating chemoresistance has been reported. Here the authors investigate the impact of chemotherapy on CAF subsets in patients with high-grade serous ovarian cancer, suggesting that residual ANTXR1+ myofibroblasts are associated with inhibition of anti-tumor immunity.

Monika Licaj
Rana Mhaidly
Fatima Mechta-Grigoriou
ResearchOpen Access12 Feb 2024
Nature Communications

Volume: 15, P: 1-27
Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial

Bagley et al. conduct a phase 1 trial to study safety and tolerability of CAR T-EGFRvIII cells administered concomitantly with PD-1 inhibition via pembrolizumab in patients with glioblastoma and show tolerability, but without signs of efficacy.

Stephen J. Bagley
Zev A. Binder
Donald M. O’Rourke
Research12 Jan 2024
Nature Cancer

Volume: 5, P: 517-531
The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression

In both focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN), kidney injury is characterised by the invasion of glomerular tufts by parietal epithelial cells (PECs). Here Lazareth et al. identify the tetraspanin CD9 as a key regulator of PEC migration, and find its upregulation in FSGS and CGN contributes to kidney injury in both diseases.

Hélène Lazareth
Carole Henique
Pierre-Louis Tharaux
ResearchOpen Access24 Jul 2019
Nature Communications

Volume: 10, P: 1-17
Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis

Crescentic rapidly progressive glomerulonephritis is a severe form of glomerula disease characterized by podocyte proliferation and migration. Here Henique et al. demonstrate that inhibition of miRNA-92a prevents kidney failure by promoting the expression of CDK inhibitor p57^Kip2 that regulates podocyte cell cycle.

Carole Henique
Guillaume Bollée
Pierre-Louis Tharaux
ResearchOpen Access28 Nov 2017
Nature Communications

Volume: 8, P: 1-15
UVB-induced DHODH upregulation, which is driven by STAT3, is a promising target for chemoprevention and combination therapy of photocarcinogenesis

Mohsen Hosseini
Léa Dousset
Hamid R. Rezvani
ResearchOpen Access24 Sept 2019
Oncogenesis

Volume: 8, P: 1-15

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Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

Residual ANTXR1+ myofibroblasts after chemotherapy inhibit anti-tumor immunity via YAP1 signaling pathway

Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial

The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression

Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis

UVB-induced DHODH upregulation, which is driven by STAT3, is a promising target for chemoprevention and combination therapy of photocarcinogenesis

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