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Automatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress

Accurate phenotyping is key to deciphering behavior. Here, authors show the utility of the software package DeepOF in supervised and unsupervised identification of distinct individual and social behavioral patterns following chronic social stress.

Joeri Bordes
Lucas Miranda
Mathias V. Schmidt
ResearchOpen Access18 Jul 2023
Nature Communications

Volume: 14, P: 1-19
Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism

This study models early life stress (ELS) to observe sex-specific effects on fear memory formation using innovative unsupervised classification together with cellular metabolism alterations in key stress brain regions, highlighting sex-specific pathways in ELS.

Joeri Bordes
Thomas Bajaj
Mathias V. Schmidt
ResearchOpen Access20 Dec 2024
Communications Biology

Volume: 7, P: 1-12
Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice

Veronika Kovarova
Joeri Bordes
Mathias V. Schmidt
ResearchOpen Access22 Oct 2024
Neuropsychopharmacology

Volume: 50, P: 556-567

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