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Nature Cell Biology (1)

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Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage

Gutierrez-Martinez et al. show that an impaired DNA damage response and reduced apoptotic priming in old haematopoietic stem cells (HSCs) contribute to the survival and expansion of damaged HSCs in the bone marrow of aged mice.

Paula Gutierrez-Martinez
Leah Hogdal
Derrick J. Rossi
Research12 Mar 2018
Nature Cell Biology

Volume: 20, P: 413-421

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Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage

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