Obesity-related metabolic syndrome is a growing health concern. The heart and kidneys are physiologically interdependent, and the pathological effects of obesity can lead to cardiorenal syndrome and, ultimately, kidney and heart failure. In this Review, the authors describe the complex interactions by which obesity might affect physiological cardiorenal interactions. They also discuss the potential roles of surgically induced weight loss and enhanced metabolic activity in the treatment of obesity-related cardiorenal syndrome.
- Wiebke Fenske
- Thanos Athanasiou
- Hutan Ashrafian
