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Showing 1–3 of 3 results
Advanced filters: Author: Lee Kroos Clear advanced filters
  • How the S2P family of intramembrane metalloproteases engage substrates has remained unclear. Here, the authors reveal cryo-EM structures showing beta-sheet augmentation as a key factor in substrate binding, linking this mechanism to all four classes of intramembrane proteases.

    • Melanie A. Orlando
    • Hunter J. T. Pouillon
    • Benjamin J. Orlando
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • Cellular pathways can be controlled through proteolysis, which allows rapid responses to changes in the environment. However, proteolysis is irreversible, so it must be carefully regulated. Here, Ron and colleagues describe how proteolysis modifies cellular behaviour and the ways in which it is controlled.

    • Eyal Gur
    • Dvora Biran
    • Eliora Z. Ron
    Reviews
    Nature Reviews Microbiology
    Volume: 9, P: 839-848