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Showing 1–14 of 14 results
Advanced filters: Author: Lena Cords Clear advanced filters

  • Some brain lesions recover in multiple sclerosis, while others do not; however, the underlying mechanisms are unclear. Here, the authors show that microglia-derived TGFα orchestrates immune control and tissue repair, and that intranasal delivery of TGFα in the autoimmune encephalomyelitis model promotes lesion resolution.

    • Lena Lößlein
    • Mathias Linnerbauer
    • Veit Rothhammer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Linnerbauer and colleagues find that HB-EGF produced by reactive astrocytes is protective during autoimmune neuroinflammation, but epigenetically suppressed during late stages.

    • Mathias Linnerbauer
    • Lena Lößlein
    • Veit Rothhammer
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 432-447

  • Myeloid cells contribute to the etiology of multiple sclerosis (MS), but the dynamics of myelopoiesis during disease progression is still unclear. Here the authors show, in both mouse models and clinical data, that myelopoiesis is differentially regulated via M-CSF modulation in different organs at distinct stages of MS, with diet and lifestyle being potential modifiers.

    • Abi G. Yates
    • Annie Khamhoung
    • Cameron S. McAlpine
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Efficient repair of demyelinated CNS lesions involves the resolution of inflammation and induction of remyelination. Berghoff et al. show that sterol synthesis in microglia is key to both processes, which can be supported by squalene therapy.

    • Stefan A. Berghoff
    • Lena Spieth
    • Gesine Saher
    Research
    Nature Neuroscience
    Volume: 24, P: 47-60

  • Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this prediction.

    • Bert Cruys
    • Brian W. Wong
    • Peter Carmeliet
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • Cancer-associated fibroblasts (CAFs) have different subtypes and play diverse roles in the tumour microenvironment. Here, the authors use single-cell RNA-seq and multiplex imaging mass cytometry data to propose a CAF classification scheme of nine subtypes across different cancer types.

    • Lena Cords
    • Sandra Tietscher
    • Bernd Bodenmiller
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • In an experimental autoimmune encephalomyelitis model in mice, a subset of astrocytes retains an epigenetically regulated memory of past inflammation, causing exacerbated inflammation upon subsequent rechallenge.

    • Hong-Gyun Lee
    • Joseph M. Rone
    • Francisco J. Quintana
    Research
    Nature
    Volume: 627, P: 865-872

  • The roles of marine plastisphere in global nitrogen cycling are largely unknown. Here, the authors indicate that the plastisphere could act as a potential source of N2O production, which is mainly regulated by the biotic denitrification

    • Xiaoxuan Su
    • Leyang Yang
    • Yong-guan Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Vascular endothelial growth factor is implicated in blood vessel development. In zebrafish, Hayashi et al. find that blood vessel development is dependent on the suppression of vascular endothelial growth factor by the phosphatase VE-PTP, which is recruited by activation of the angiopoietin receptor Tie2.

    • Makoto Hayashi
    • Arindam Majumdar
    • Lena Claesson-Welsh
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-15

  • Acquired resistance to immune checkpoint inhibitors limits therapeutic success in non-small-cell lung cancer, however, the underpinning immune parameters are largely unknown. Here authors distinguish resistance types based on immune cell infiltration, immune checkpoint molecule and cytokine expression level, using paired samples from patients in the sensitive and in the resistant disease phase.

    • Stefanie Hiltbrunner
    • Lena Cords
    • Alessandra Curioni-Fontecedro
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14