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Endothelial sensitivity to pro-fibrotic signals links systemic exposure to pulmonary fibrosis

Lena Möbus
Laura Ylä-Outinen
Dario Greco
ResearchOpen Access07 Jul 2025
Cell Death & Disease

Volume: 16, P: 1-12
Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota

Microbiome composition is influenced by genetics, although the specific host genetic factors responsible are not well known. Here, the authors performed a genome-wide meta-analysis to discover host genetic effects on skin microbiota and finding potential causal effects of microbiota composition on skin diseases.

Lucas Moitinho-Silva
Frauke Degenhardt
Malte Christoph Rühlemann
ResearchOpen Access19 Oct 2022
Nature Communications

Volume: 13, P: 1-12
Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans

Leprosy, caused by infection with Mycobacterium leprae, was common in Europe in the Middle Ages. Here, Krause-Kyora et al. analyze ancient DNA from a medieval Danish leprosarium to assemble 10 complete bacterial genomes and perform association analysis of the DRB1*15:01 allele with risk of leprosy infection.

Ben Krause-Kyora
Marcel Nutsua
Almut Nebel
ResearchOpen Access01 May 2018
Nature Communications

Volume: 9, P: 1-11

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