Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–12 of 12 results
Advanced filters: Author: Lena Ström Clear advanced filters

  • Autoimmune Addison’s disease is a rare complex disease, which has not yet been characterized by non-biased genetic studies. Here, the authors perform the first GWAS for the disease, identifying nine loci including two coding variants in the gene Autoimmune Regulator (AIRE).

    • Daniel Eriksson
    • Ellen Christine Røyrvik
    • Eystein Sverre Husebye
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Conditional degradation of proteins is instrumental to advance our knowledge of cell biology but has been lacking for organelles like mitochondria. Here, the authors develop a proteolysis system based on the mycoplasma Lon protease that functions selectively within mitochondria in yeast and human cells.

    • Swastika Sanyal
    • Anna Kouznetsova
    • Camilla Björkegren
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • A late-autumn shoulder is consistently observed in the seasonal cycles of atmospheric methane at high latitude sites, but the sources responsible remain uncertain. This study reports methane flux measurements from a high Arctic setting during the onset of soil freezing. The integral of the emissions during this freeze-in period amount to approximately the same amount of methane emitted during the entire summer season. It is found that the observed early winter emission burst improves the agreement between the simulated seasonal cycle and atmospheric data from latitudes north of 60°N. The results suggest that permafrost associated freeze-in bursts of methane emissions from tundra regions could be an important component of the seasonal distribution of methane emissions from high latitudes.

    • Mikhail Mastepanov
    • Charlotte Sigsgaard
    • Torben R. Christensen
    Research
    Nature
    Volume: 456, P: 628-630

  • During replication, topological stress builds ahead of the polymerase. Current models propose that linear eukaryotic chromosomes are divided into topological domains, and that stress is relieved by the activity of a topoisomerase. Here, it is found that replication stress seems to be present throughout the chromosome, rather than in domains, and that the relief of stress in longer chromosomes is facilitated by the activity of the cohesin/condensin-like Smc5/6 complex as well as by topoisomerase. They propose that the Smc5/6 complex prevent formation of topological tension ahead of the replication fork by promoting fork rotation, leading to the formation of sister chromatin intertwinings behind.

    • Andreas Kegel
    • Hanna Betts-Lindroos
    • Camilla Sjögren
    Research
    Nature
    Volume: 471, P: 392-396

  • In order to find a general treatment for cancer, this study found that MTH1 activity is essential for the survival of transformed cells, and isolated two small-molecule inhibitors of MTH1, TH287 and TH588 — in the presence of these inhibitors, damaged nucleotides are incorporated into DNA only in cancer cells, causing cytotoxicity and eliciting a beneficial response in patient-derived mouse xenograft models.

    • Helge Gad
    • Tobias Koolmeister
    • Thomas Helleday
    Research
    Nature
    Volume: 508, P: 215-221

  • In this study, the authors use measures of carbon-14 in neuronal DNA from human stroke patient cortical tissue samples to show that, unlike previous studies done in rodents, they do not find any evidence of increased neurogenesis after an ischemic injury. In addition, DNA damage assays suggest that there is no increase in DNA rearrangement after this insult.

    • Hagen B Huttner
    • Olaf Bergmann
    • Jonas Frisén
    Research
    Nature Neuroscience
    Volume: 17, P: 801-803