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Showing 1–2 of 2 results
Advanced filters: Author: Lenka Bittova Clear advanced filters

  • Suv39h1 is a histone methyltransferase that methylates H3K9 residues in heterochromatic regions of the genome. An approach using semisynthetic chromatin reveals a mechanism for heterochromatin spreading in which H3K9 trimethylation anchors and activates Suv39h1 for modification of proximal lysines.

    • Manuel M Müller
    • Beat Fierz
    • Tom W Muir
    Research
    Nature Chemical Biology
    Volume: 12, P: 188-193

  • A synthetic library of nucleosomes, each with a DNA-barcode characteristic for a defined post-translational modification (PTM), is used to probe PTM-based recruitment and modulation of histone mark readers and writers.

    • Uyen T T Nguyen
    • Lenka Bittova
    • Tom W Muir
    Research
    Nature Methods
    Volume: 11, P: 834-840