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Showing 1–2 of 2 results
Advanced filters: Author: Lennart Lindfors Clear advanced filters

  • Lipid nanoparticles (LNPs) fate after up take by cells is important for therapies. Here, the authors report on key barriers limiting RNA delivery by LNPs, including restricted endosomal escape, ESCRT-mediated membrane repair, and separation of lipid and RNA components during endosomal sorting.

    • Johanna M. Johansson
    • Hampus Du Rietz
    • Anders Wittrup
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Lipid nanoparticles (LNPs) are potential platforms for RNA-based therapeutics, but the fate of LNP-RNAs upon internalization into the cell is unclear. Here, the authors show that LNP-mRNAs and ionizable lipids escape the endosomes and are re-released via extracellular vesicles which could deliver the functional mRNA to other cells.

    • Marco Maugeri
    • Muhammad Nawaz
    • Hadi Valadi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15