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Showing 1–13 of 13 results
Advanced filters: Author: Leo Scheller Clear advanced filters

  • A computational deep learning approach is used to design synthetic proteins that target the neosurfaces formed by protein–ligand interactions, with applications in the development of new therapeutic modalities such as molecular glues or cell-based therapies.

    • Anthony Marchand
    • Stephen Buckley
    • Bruno E. Correia
    ResearchOpen Access
    Nature
    Volume: 639, P: 522-531

  • Development of chemically responsive bandpass filters mimics the signal-processing abilities of electronic circuits in mammalian cells by responding to chemical concentrations within a specific range and rejecting ones outside that range.

    • Sailan Shui
    • Leo Scheller
    • Bruno E. Correia
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 586-593

  • Merging the generalized extracellular molecule sensor (GEMS) system with screening designed ankyrin repeat proteins (DARPins) identifies an advanced modular bispecific extracellular receptor (AMBER) for detection of fibrinogen degradation products.

    • Tobias Strittmatter
    • Yidan Wang
    • Martin Fussenegger
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 18, P: 1125-1134

  • Beginning with a functional site and building a supporting scaffold around it enables the de novo design of proteins with distinct binding motifs for use in biosensors to detect antibody responses and as ligands of synthetic signaling receptors.

    • Che Yang
    • Fabian Sesterhenn
    • Bruno E. Correia
    Research
    Nature Chemical Biology
    Volume: 17, P: 492-500

  • Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches active in cells.

    • Sailan Shui
    • Pablo Gainza
    • Bruno E. Correia
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Engineered erythropoietin receptor scaffolds equipped with extracellular sensor domains and modular intracellular domains that couple to endogenous signaling pathways enable modular reprogramming of designer membrane-bound receptors.

    • Leo Scheller
    • Tobias Strittmatter
    • Martin Fussenegger
    Research
    Nature Chemical Biology
    Volume: 14, P: 723-729

  • One method of controlling protein degradation is through the use of degrons. Here the authors present a toolbox of characterised degrons as a library to fine-tune biological gene-expression systems. Its application is demonstrated by a set of tunable synthetic pulse generators in mammalian cells.

    • Hélène Chassin
    • Marius Müller
    • Martin Fussenegger
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Phosphoregulation is a key mechanism of signal processing. Here the authors build a phosphoregulated relay system in mammalian cells for orthogonal signal transduction.

    • Leo Scheller
    • Marc Schmollack
    • Martin Fussenegger
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Current cellular rewiring designs are typically tailored to detect single inputs. Here the authors present GEARs that function independently of engineered receptor/reporter systems and directly reroute endogenous signaling pathways to alternative genomic loci using dCas9-directed gene expression.

    • Krzysztof Krawczyk
    • Leo Scheller
    • Martin Fussenegger
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Control of transgene expression should ideally be easy and with minimal side effects. Here the authors present a synthetic biology-based approach in which the caffeine in coffee regulates a genetic circuit controlling glucagon-like peptide 1 expression in diabetic mice.

    • Daniel Bojar
    • Leo Scheller
    • Martin Fussenegger
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Engineering of nonimmune cells with a cell-contact sensor and antigen recognition domains enables cell-contact-dependent sensor cell signaling and effector molecule production directed to attack target cells, providing an alternative strategy to chimeric antigen receptor T-cell (CAR-T) technology.

    • Ryosuke Kojima
    • Leo Scheller
    • Martin Fussenegger
    Research
    Nature Chemical Biology
    Volume: 14, P: 42-49