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Showing 1–8 of 8 results
Advanced filters: Author: Leonid P Savtchenko Clear advanced filters

  • Membrane depolarization during increased neuronal activity as seen during epilepsy has been suggested to easily reverse neuronal GABA transporters. Here the authors use modelling and experimental data and challenge this view by showing that synaptic GABA release during excessive neuronal firing averts reversal of GABA uptake.

    • Leonid Savtchenko
    • Maria Megalogeni
    • Ivan Pavlov
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Astrocytes have gained increasing attention for their roles in regulating neural circuits via neurotransmitter uptake, K + buffering, and ability to signal via Ca2 + transients. Here, the authors develop a computational modelling environment for astrocytes, akin to the NEURON environment, called ASTRO.

    • Leonid P. Savtchenko
    • Lucie Bard
    • Dmitri A. Rusakov
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • The authors use patch clamp recordings and computer simulations to determine the number of molecules of glutamate released at two central synapses. They find that the amount of glutamate released maximizes the synaptic current per glutamate molecule and maximizes the signal's information content, suggesting that synapses operate under conditions that optimize resources.

    • Leonid P Savtchenko
    • Sergiy Sylantyev
    • Dmitri A Rusakov
    Research
    Nature Neuroscience
    Volume: 16, P: 10-12

  • Neuroscience is going nanoscopic, but can it still rely on classical electrophysiology? In this Review, Savtchenko, Poo and Rusakov argue that accurate interpretation of physiological observations on the nanoscale must account for electrodiffusion phenomena arising from local perturbations of ionic concentrations.

    • Leonid P. Savtchenko
    • Mu Ming Poo
    • Dmitri A. Rusakov
    Reviews
    Nature Reviews Neuroscience
    Volume: 18, P: 598-612

  • In neurons, GABAA receptors mediate feed-forward inhibition by shunting excitatory currents and hyperpolarizing neurons. Here, the authors show that the hyperpolarization-activated mixed cation current is critical for determining the resting membrane potential and reversal potential for GABAA-mediated currents.

    • Ivan Pavlov
    • Annalisa Scimemi
    • Matthew C. Walker
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-9

  • Ambient levels of the neurotransmitter GABA tonically activate GABAA. Song et al.show that GABA can have both excitatory and inhibitory effects on hippocampal interneurons and find that low levels of GABA-mediated conductance are excitatory, whereas higher levels result in shunting inhibition.

    • Inseon Song
    • Leonid Savtchenko
    • Alexey Semyanov
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-10