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Showing 1–5 of 5 results
Advanced filters: Author: Leonie Unterholzner Clear advanced filters

  • DNA damage can be sensed as a danger signal by the innate immune system. Bournique et al. show that the transcription stress caused by DNA lesions can also initiate inflammation by causing the direct release of cytokine IL-1α, which then drives NF-κB activation in neighboring cells.

    • Thomas D. J. Walker
    • Jessica P. Morris
    • Leonie Unterholzner
    News & Views
    Nature Structural & Molecular Biology
    Volume: 32, P: 591-594

  • Foreign nucleic acids trigger innate immune sensors. Bowie and colleagues identify the PYHIN protein IFI16 as an innate duplex DNA sensor that triggers IFN-β production in a STING-TBK1-IRF3 signaling pathway.

    • Leonie Unterholzner
    • Sinead E Keating
    • Andrew G Bowie
    Research
    Nature Immunology
    Volume: 11, P: 997-1004

  • The role of IFI16 as a DNA sensor is highly controversial. With support from aNature Communications back-to-back publication from Jønsson et al., the authors here provide functional evidence that IFI16 is involved in DNA sensing via the cGAS-STING pathway in human keratinocytes.

    • Jessica F. Almine
    • Craig A. J. O’Hare
    • Leonie Unterholzner
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • This Review highlights how understanding the mechanisms by which viruses evade and subvert host signalling by pattern-recognition receptors has provided insights into the function of these signalling pathways, the host proteins that are involved and ways in which the pathways might be manipulated therapeutically.

    • Andrew G. Bowie
    • Leonie Unterholzner
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 911-922