The control of complex cellular events relies on precise regulation of signalling molecules. The activity of many such proteins is controlled by adding a phosphate group to certain amino acids such as tyrosine, serine and threonine. A well-known motif -- the SH2 domain -- binds to phosphotyrosine residues. And a new family of proteins that bind phosphoserine and phosphothreonine is now emerging.
- Michael B. Yaffe
- Lewis C. Cantley
