Search

Cobalt-free Mn-based lithium metal batteries suffer from serious Mn dissolution and lithium dendrite problems. Here, authors propose ferrocene hexafluorophosphate as an electrolyte additive to achieve dynamic doping of positive electrode and interphase stabilization of electrodes.

A new study shows EMP1 protects hematopoietic stem cells by suppressing sphingolipid metabolism and ER stress. EMP1 interacts with CERS2 to limit dihydroceramide production, which causes protein aggregation when elevated.

Lithium-ion batteries with fast-charging properties are urgently needed for wide adoption of electric vehicles. Here, the authors show a fast charging/discharging and long-term stable electrode made from a mixed electronic/ionic conductor material enabled by a space charge mechanism.

This study introduces the Cattle Cell Atlas, a single-cell expression resource including 1,793,854 cells from 59 tissues. Integrative analyses leveraging this atlas provide insights into the biology underlying bovine monogenic and complex traits.

Fast charging of high-energy batteries is limited by electrolyte instability under rising overpotential. A self-adaptive electrolyte overcomes this by dynamically expanding its stability window during charging, enabling efficient zinc- and lithium-metal battery operation.

Li et al. show that the TFE3 driver fusion transcriptionally upregulates an OXPHOS programme in translocation renal cell carcinoma that renders this cancer vulnerable to reductive stress, induced by imbalance of reducing equivalents.

The role of the tumour microenvironment in the response to immune checkpoint inhibitors in metastatic melanoma remains poorly understood. Here, single cell profiling of metastatic melanoma samples identifies associations of the mature dendritic enriched in immunoregulatory molecules subtype with immunotherapy response.

This study reports age-dependent negative correlations between temporal changes in maximal leaf area index and growing season length, indicating contrasting leaf acclimation strategies driving vegetation greening in young versus old deciduous broadleaf forests.

The mechanisms of resistance to therapy in gastric cancer remain to be explored. Here, proteomic profiling of 206 tumour tissues from patients treated with chemotherapy and anti-HER2-based therapy results in the identification of four molecular subtypes and the development of prognostic models.

Stable lithium metal electrodes are needed to produce high-energy batteries. Here, authors reported poly(2-hydroxyethyl acrylate-co-sodium benzenesulfonate) as a lithium metal protective layer and the production of a 490 Wh/kg class Li | |LiNi_0.83Co_0.11Mn_0.06O₂ pouch cell.

Through a synthetic-bioinformatic natural product approach combined with peptide optimization, a nature inspired antibiotic, paenimicin, was identified from Paenibacillaceae family. Paenimicin features a dual-target mechanism of action and shows broad-spectrum activities against multi-drug-resistant pathogens both in vitro and in vivo.

Li et al. introduced tract-geometry coupling (TGC) to quantify the coupling between white matter tracts and cortical geometry in the human brain, shedding light on how the brain’s wiring and shape evolve together and its support for behavior and growth.

A robust all-organic interfacial protective layer towards ultrahigh-rate and large-capacity Li metal anodes is proposed by rational integration of porous polymer-based molecular brushes with single-ion-conductive lithiated Nafion.

PKM2 is involved in the aging process but the mechanism remains elusive. Here, the authors show that PKM2 forms aggregates during aging and identify two small molecules which can dissolve the PKM2 aggregates and delay aging.

Long-term stability is a key challenge for ruthenium-based oxygen evolution reaction (OER) catalysts. Here, the authors present a RuO2/LiCoO2 catalyst with dynamic Li dissolution, which weakens the covalency of the Ru-O bond to prevent the lattice oxygen mechanism, thereby ensuring stable acidic OER.

Alternative expression analysis by sequencing (ALEXA-seq) aligns RNA-seq reads from different cell types to a database of alternative expression sequence features and quantifies isoforms that are differentially expressed between samples.

An electrolyte design strategy based on a group of soft solvents is used to achieve lithium-ion batteries that operate safely under extreme conditions without lithium plating and with the capability of fast charging.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Single-cell RNA sequencing, whole-exome sequencing and spatial transcriptome sequencing of gallbladder adenocarcinomas from 75 patients stratifies the disease into groups with distinct clinical outcomes.

Rice-infecting arboviruses adopt convergent strategies to overcome host defenses. Here, the authors show that viral proteins from distinct rice viruses boost OsTSN1 nuclease activity to suppress rice antiviral RNA decay immune response through promoting its phase separation and multimerization.

Tailoring the oxygen redox reactivity in Li-rich cathode is crucial for developing high-energy batteries. Here, the authors report a strategy to obtain a flexible crystal structure and enhance the oxygen redox reversibility.

Current prognostic biomarkers for colorectal cancer (CRC) tend to lack generalisability across different cohorts and platforms. Here, the authors introduce PIANOS, a classifier for stratifying CRC patients into distinct risk groups across different platforms and cohorts, which allows predicting clinical outcomes and therapies.

Wang, Fan, Guo, and colleagues present MorphDiff, a transcriptome-guided latent diffusion model that accurately predicts cell morphological responses to perturbations, enhancing MOA identification and phenotypic drug discovery.

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance in multiple worm disease models, extending healthspan.

Triangle-beam interference structured illumination microscopy leverages radially polarized beams to generate two-dimensional lattice illumination patterns. The technique enables a temporal resolution of 242 Hz, spatial resolution of 100 nm and continuous imaging of neuronal growth for up to 13 h.

Neural circuit mechanisms underlying feeding behavior regulation are not fully understood. Here authors provide quantitative mapping of the brain-wide input and output configuration of tuberal nucleus somatostatin neurons, a key player of feeding regulation, in mouse brain for a deeper understanding of the feeding regulation network.

The synthesis of drug-like saturated cycloalkanes is more complex than their two-dimensional aromatic analogues. A formidable challenge lies in synthesizing all isomers of multi-substituted cycloalkanes. Now a cobalt-catalysed system enables diastereodivergent hydroalkylation of substituted methylenecyclohexanes with exceptional versatility. Strategic manipulation of ligands provides access to all isomers of disubstituted cyclohexanes, piperidines and multi-substituted cyclohexanes.

All-solid-state lithium sulfur batteries may avoid some of the drawbacks of their liquid electrolyte counterparts. Here, the authors elucidate the composition of discharge products in all-solid-state cells using spectroscopic techniques and propose a strategy to control the discharge product.

Electrochemical conversion of nitrate into ammonia offers a method for mitigating nitrate pollution in water. Here the authors report the electrochemical nitrate-to-ammonia conversion using high-entropy oxide Mg_0.2Co_0.2Ni_0.2Cu_0.2Zn_0.2O and find that the Co spin states are crucial for synergistic ammonia generation.

How cell cycling coordinates with cell survival and death remains unclear. Here, the authors reveal a suppressive effect of cell cycle arrest on ferroptosis and propose a ferroptosis-inducing approach to treat slow-cycling, therapy-resistant cancers.

An asteroseismic and spectroscopic analysis of lithium-rich stars improves their classification based on the distributions of lithium, nitrogen and mass, and reveals that most of these evolved stars are red clump rather than red giant branch stars.

Proteases of the caspase family are important regulators of apoptosis. Here, Zhang et al. present a genetically encoded protein biosensor that fluoresces if cleaved by caspase-3-like proteases, allowing real-time measurements of apoptosis in cells.