Bicyclic boronates are present in various bioactive molecules and functional materials, however, the efficient construction of this skeleton mainly relies on transition-metal-catalyzed processes. Here, the authors develop a practical preparation of bicyclic boronates via metal-free heteroatom-directed alkenyl sp2-C–H borylation and apply it to the synthesis of antibacterial agent QPX7728.
- Pei-Ying Peng
- Gui-Shan Zhang
- Ping Tian
