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Age is just a number.

Liam Hogan
Comments & Opinion14 Aug 2024
Nature
Shared and distinct genetic etiologies for different types of clonal hematopoiesis

Types of clonal hematopoiesis (CH) differ in frequency and fitness. These findings uncover shared genetic architecture, suggest evolutionary trade-offs between CH types, and detail elevated leukemia risk in individuals with overlapping types of CH.

Derek W. Brown
Liam D. Cato
Mitchell J. Machiela
ResearchOpen Access08 Sept 2023
Nature Communications

Volume: 14, P: 1-13
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia

Modeling a rare bone marrow failure disorder due to haploinsufficiency for the MECOM transcription factor identifies a human hematopoietic stem cell regulatory network, which is co-opted by high-risk leukemias.

Richard A. Voit
Liming Tao
Vijay G. Sankaran
ResearchOpen Access15 Dec 2022
Nature Immunology

Volume: 24, P: 69-83
Variant to function mapping at single-cell resolution through network propagation

SCAVENGE identifies causal variants from single-cell epigenomic data.

Fulong Yu
Liam D. Cato
Vijay G. Sankaran
ResearchOpen Access06 Jun 2022
Nature Biotechnology

Volume: 40, P: 1644-1653
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26