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Showing 1–4 of 4 results
Advanced filters: Author: Lian-Ge Chen Clear advanced filters

  • Genome synthesis is moving into the multicellular era. This study redesigned and replaced a 155 kb chromosomal region with synthetic sequence in the model moss Physcomitrium patens. The simplified sequence obtains the correct epigenetic landscape.

    • Lian-Ge Chen
    • Tianlong Lan
    • Yuling Jiao
    Research
    Nature Plants
    Volume: 10, P: 228-239

  • Owing to advances in genome sequencing and editing, a genome can now be redesigned, synthesized and introduced into cells as desired. This Review discusses plant genome synthesis, highlighting bottom-up genome design, large-fragment assembly and site-directed targeting.

    • Tianlong Lan
    • Lian-Ge Chen
    • Yuling Jiao
    Reviews
    Nature Reviews Bioengineering
    Volume: 3, P: 875-889

  • The authors present the design principles of a synthetic earthmoss (Physcomitrium patens) genome. To aid future genome design projects, they also develop GenoDesigner, a software package that provides users with an intuitive graphical interface to efficiently manipulate genomic sequences.

    • Wenfei Yu
    • Shuo Zhang
    • Junbiao Dai
    Reviews
    Nature Plants
    Volume: 10, P: 848-856