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Advanced filters: Author: Liana N. Bonanno Clear advanced filters

Exercise plasma boosts memory and dampens brain inflammation via clusterin

Plasma from voluntarily running mice reduces baseline expression of neuroinflammatory genes and experimentally induced brain inflammation when infused into sedentary mice.

Zurine De Miguel
Nathalie Khoury
Tony Wyss-Coray
Research08 Dec 2021
Nature

Volume: 600, P: 494-499
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

The detrimental effects of aged blood on cognition and nervous system function in mice can be combatted by targeting brain endothelial cell dysfunction via inhibition of aberrant VCAM1 signaling at the blood–brain barrier.

Hanadie Yousef
Cathrin J. Czupalla
Tony Wyss-Coray
Research13 May 2019
Nature Medicine

Volume: 25, P: 988-1000
Molecular hallmarks of heterochronic parabiosis at single-cell resolution

A transcriptomics study demonstrates cell-type-specific responses to differentially aged blood and shows young blood to have restorative and rejuvenating effects that may be invoked through enhanced mitochondrial function.

Róbert Pálovics
Andreas Keller
Tony Wyss-Coray
Research02 Mar 2022
Nature

Volume: 603, P: 309-314
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

CD22 inhibits microglial phagocytosis in the ageing brain, and treatment with a CD22-blocking antibody restores microglial homeostasis and cognitive function in ageing mice.

John V. Pluvinage
Michael S. Haney
Tony Wyss-Coray
Research03 Apr 2019
Nature

Volume: 568, P: 187-192
Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19

Mayara Bearse
Yin P. Hung
James R. Stone
Research17 Mar 2021
Modern Pathology

Volume: 34, P: 1345-1357