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Showing 1–4 of 4 results
Advanced filters: Author: Libbey White Clear advanced filters

  • Analyses of samples from patients with acute myeloid leukaemia reveal that drug response is associated with mutational status and gene expression; the generated dataset provides a basis for future clinical and functional studies of this disease.

    • Jeffrey W. Tyner
    • Cristina E. Tognon
    • Brian J. Druker
    Research
    Nature
    Volume: 562, P: 526-531

  • FLT3 is commonly mutated in acute myeloid leukaemia and treatment with FLT3 inhibitors often ends with relapse. Here, the authors perform exome sequencing of samples from patients treated with the FLT3 inhibitor, crenolanib, to show that resistance occurs due to diverse molecular mechanisms, not primarily due to secondary FLT3 mutations.

    • Haijiao Zhang
    • Samantha Savage
    • Jeffrey W. Tyner
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13