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Showing 1–9 of 9 results
Advanced filters: Author: Libin Bai Clear advanced filters

  • Photo-crosslinking polymerization facilitates precise control of hydrogel formation for various applications including tissue engineering, but most existing photo-crosslinking methods fail to achieve deep-tissue penetration, especially within bone structures. Here the authors report a strategy of low-dose X-ray-activated polymerization that enables deep-tissue hydrogel formation.

    • Hailei Zhang
    • Boyan Tang
    • Gang Han
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • In heart muscle cells, sarcoplasmic reticulum calcium overload leads to spontaneous calcium waves that can cause arrhythmias and sudden cardiac death. S.R. Wayne Chen and his colleagues now detail the molecular mechanism by which intra–sarcoplasmic reticulum calcium ions interact with the gate of the calcium release channel RyR2, explaining how calcium waves are initiated and thereby contribute to calcium-triggered arrhythmias.

    • Wenqian Chen
    • Ruiwu Wang
    • S R Wayne Chen
    Research
    Nature Medicine
    Volume: 20, P: 184-192

  • The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity. Here, the authors combine molecular dynamics simulations, mutagenesis, and electrophysiology to provide mechanistic insights into how lipophilic molecules alter gating kinetics and K+ currents of hERG1.

    • Williams E. Miranda
    • Jiqing Guo
    • Sergei Yu. Noskov
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Two series of fluorescent glycopolymers (boronic acid derivatives, PG-PFE, and borate derivatives, PG-PFW) were synthesized through different methods. Compared with the PG-PFE samples, the PG-PFW samples had a higher grafting ratio due to the highly efficient Williamson reaction. The fluorescent glycopolymers possessed good water solubility, low cytotoxicity and selective responsiveness toward H2O2. Meantime, the fluorescent glycopolymers were imaged only in cellular mitochondria based on the fact that endogenous H2O2 is mainly distributed in cellular mitochondria.

    • Yuangong Zhang
    • Libin Bai
    • Xinwu Ba
    Research
    Polymer Journal
    Volume: 52, P: 481-491

  • The aqueous solution of hyperbranched poly(bis-acrylamide)s (HPEAMs) prepared by reversible addition-fragmentation chain-transfer (RAFT) polymerization are of lower critical solution temperature (LCST), which also can response to HCO3-. The structure of HPEAM is characterized by the presence of carboxyl groups, thioester groups, and diamine bisacrylamide structural units. The study will reveal how they act in solution to cause these phenomena.

    • Qian Zhou
    • Bing Liu
    • Libin Bai
    Research
    Polymer Journal
    Volume: 55, P: 1295-1305