Chronic inflammation like psoriasis can be treated with anti-IL-23 antibodies, but relapses often occur after treatment cessation. Here the authors show that CCR7+ dendritic cells (DC) persist in human psoriasis skin, while depletion of CCR7+ DC abrogates psoriasis in mouse models, thereby hinting a function of IL-23 derived from CCR7+ DC in chronic inflammation.
- Yang Sun
- Fangzhou Lou
- Honglin Wang