Nonheme Fe enzymes with open coordination sites hold the potential for advancing new-to-nature reactions. Here a plant-derived nonheme Fe enzyme, 1-aminocyclopropane-1-carboxylic acid oxidase, is evolved and repurposed to catalyze 1,3-nitrogen migration reactions, enabling the enantioselective synthesis of noncanonical amino acids.
- Liu-Peng Zhao
- Huichong Liu
- Yang Yang
