Nature Search

Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

Folic acid is routinely recommended for women trying to conceive to ensure proper fetal development. Here, the authors perform a large epigenomics study to examine which fetal epigenetic changes are associated with varied maternal plasma folate levels.

Bonnie R. Joubert
Herman T. den Dekker
Stephanie J. London
ResearchOpen Access10 Feb 2016
Nature Communications

Volume: 7, P: 1-8
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

The genetic basis of atopic dermatitis is not fully understood. Here, the authors find 91 genetic loci associated with atopic dermatitis in a GWAS of >1million individuals, which highlight the importance of systemic immune regulation.

Ashley Budu-Aggrey
Anna Kilanowski
Lavinia Paternoster
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-18
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Our understanding of the functional link between differential DNA methylation and type 2 diabetes and obesity remains limited. Here the authors present a blood-based EWAS of fasting glucose and insulin among 4808 non-diabetic Europeans and identify nine CpGs not previously implicated in glucose, insulin homeostasis and diabetes.

Jun Liu
Elena Carnero-Montoro
Cornelia M. van Duijn
ResearchOpen Access13 Jun 2019
Nature Communications

Volume: 10, P: 1-11
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Birthweight has been found to associate with later-life health outcomes. Here the authors perform a meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, identifying differentially methylated CpGs in neonatal blood that associate with birthweight.

Leanne K. Küpers
Claire Monnereau
Janine F. Felix
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-11
Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Johannes Waage
Marie Standl
Klaus Bønnelykke
Amendments and Corrections16 Aug 2018
Nature Genetics

Volume: 50, P: 1343
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

The authors perform meta-analysis of GWAS studies for asthma from multiancestral cohorts. They identify five new loci and find that the asthma-associated loci are enriched near enhancer marks in immune cells.

Florence Demenais
Patricia Margaritte-Jeannin
Dan L. Nicolae
Research22 Dec 2017
Nature Genetics

Volume: 50, P: 42-53
Large-scale association analyses identify host factors influencing human gut microbiome composition

Analysis of human genotypes and 16S microbiome data of 18,473 individuals from 25 cohorts through a genome-wide association study, a phenome-wide association study and Mendelian randomization identifies host genetic and microbial trait associations.

Alexander Kurilshikov
Carolina Medina-Gomez
Alexandra Zhernakova
Research18 Jan 2021
Nature Genetics

Volume: 53, P: 156-165
Perinatal Stress Influences Lymphocyte Subset Counts in Neonates. The Generation R Study

Liesbeth Duijts
Liesbeth E Bakker-Jonges
Henriëtte A Moll
Research01 Mar 2008
Pediatric Research

Volume: 63, P: 292-298
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Genome-wide association analyses identify new risk loci for allergic rhinitis and for sensitization to inhalant allergens. The associated regions implicate immune-related pathways, including innate and adaptive IgE-related mechanisms.

Johannes Waage
Marie Standl
Klaus Bønnelykke
Research16 Jul 2018
Nature Genetics

Volume: 50, P: 1072-1080
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

Lavinia Paternoster and colleagues report a meta-analysis of genome-wide association studies of atopic dermatitis. They report three newly identified associated loci near OVOL1 and ACTL9 and in KIF3A.

Lavinia Paternoster
Marie Standl
Stephan Weidinger
Research25 Dec 2011
Nature Genetics

Volume: 44, P: 187-192
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

Klaus Bønnelykke and colleagues identify a common variant in CDHR3 associated with early childhood asthma with severe exacerbations. CDHR3 encodes a cell adhesion protein expressed at high levels in airway epithelium, suggesting a role for altered epithelial integrity in asthma pathogenesis.

Klaus Bønnelykke
Patrick Sleiman
Hans Bisgaard
Research17 Nov 2013
Nature Genetics

Volume: 46, P: 51-55
Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Charlotte King
Amanda McKenna
Daniel B. Hawcutt
ReviewsOpen Access17 Jan 2020
The Pharmacogenomics Journal

Volume: 20, P: 621-628
Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study

Chalana M. Sol
Susana Santos
Vincent W. V. Jaddoe
Research12 Sept 2020
International Journal of Obesity

Volume: 44, P: 2225-2235
Maternal body mass index, gestational weight gain, and childhood abdominal, pericardial, and liver fat assessed by magnetic resonance imaging

Susana Santos
Claire Monnereau
Vincent W. V. Jaddoe
Research19 Sept 2018
International Journal of Obesity

Volume: 43, P: 581-593
Correction to: Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study

Chalana M. Sol
Susana Santos
Vincent W. V. Jaddoe
Amendments and Corrections26 Apr 2022
International Journal of Obesity

Volume: 46, P: 1411-1412
Correction: Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritization

Charlotte King
Amanda McKenna
Daniel B. Hawcutt
Amendments and CorrectionsOpen Access23 Jul 2020
The Pharmacogenomics Journal

Volume: 20, P: 746
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Lavinia Paternoster and colleagues report the results of a large, multi-ancestry genome-wide association study of atopic dermatitis. They identify ten new susceptibility loci harboring candidate genes involved in innate host defense and T cell function.

Lavinia Paternoster
Marie Standl
Stephan Weidinger
Research19 Oct 2015
Nature Genetics

Volume: 47, P: 1449-1456
Key recommendations for primary care from the 2022 Global Initiative for Asthma (GINA) update

Mark L. Levy
Leonard B. Bacharier
Helen K. Reddel
ReviewsOpen Access08 Feb 2023
npj Primary Care Respiratory Medicine

Volume: 33, P: 1-13
Visceral adiposity and respiratory outcomes in children and adults: a systematic review

Tong Wu
Marc R. Jahangir
Edwin H. G. Oei
Reviews21 Feb 2022
International Journal of Obesity

Volume: 46, P: 1083-1100
Preventing bronchopulmonary dysplasia: new tools for an old challenge

María Álvarez-Fuente
Laura Moreno
Maria Jesús del Cerro
Reviews21 Nov 2018
Pediatric Research

Volume: 85, P: 432-441

Search

Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Large-scale association analyses identify host factors influencing human gut microbiome composition

Perinatal Stress Influences Lymphocyte Subset Counts in Neonates. The Generation R Study

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study

Maternal body mass index, gestational weight gain, and childhood abdominal, pericardial, and liver fat assessed by magnetic resonance imaging

Correction to: Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study

Correction: Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritization

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Key recommendations for primary care from the 2022 Global Initiative for Asthma (GINA) update

Visceral adiposity and respiratory outcomes in children and adults: a systematic review

Preventing bronchopulmonary dysplasia: new tools for an old challenge

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