Here the authors perform a genome wide association study of 204,747 Estonian Biobank participants revealing 214 BMI loci. Reported signals include ADGRL3, PTPRT, and a protein-truncating POMC variant with strong BMI effects, implicating leptin-melanocortin pathways and highlighting targets for obesity intervention.
- Erik Abner
- Kanwal Batool
- Tõnu Esko
