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Inflammatory bowel disease (IBD) is a chronic immune-mediated condition. This study presents a drug-free treatment strategy for IBD that targets bacterial adhesion, utilizing mannan oligosaccharide-loaded porous microgels to selectively capture adherent-invasive E. coli and competitively inhibit bacterial colonization on the gut epithelium.

Silicon–hydride materials are attractive candidates for the photoreduction of carbon dioxide into fuels, although they have only worked stoichiometrically so far. Now, Ozin and co-workers show how decorating silicon nanosheets with palladium nanoparticles renders the process catalytic.

Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the authors show that TIGIT limits the differentiation of inflammatory Th1 and Th17 cells via a metabolic-epigenetic mechanism, which involves the inhibition of CD28-mediated PI3K/AKT/mTOR costimulatory signaling.

Klotho is an anti-ageing protein whose expression is downregulated in chronic kidney disease, but the large size of the protein makes it challenging to deliver therapeutically. Here, the authors develop a Klotho-derived peptide, and show that it recapitulates the anti-fibrotic action of Klotho and prevents kidney fibrosis in mice by targeting TGF-β signalling.

High-quality, non-layered 2D β-Bi₂O₃ crystals are grown using a vapour–liquid–solid–solid growth technique. These crystals demonstrate promising properties for p-channel field-effect transistors.

Here, particulate matter metrics are assessed and associated with sand and dust storm health risks. The oxidative potential and the environmentally persistent free radicals of particulate matter could be used to develop effective sand and dust risk prevention in dust-prone countries.

Nanocarriers are promising in tumour-targeting drug delivery but limited by their delivery efficiency within tumour microenvironment (TME). Here the authors report the development of lipoic acid boronophenylalanine derivatives linked by short-chain PEG spacers which can self-assemble into versatile vesicles under TME-specific pH for targeted cancer therapy.

This study reveals gut microbial and metabolomic features associated with the severity of frailty, demonstrating that these microbial features outperform traditional assessment tools in identifying individuals at high risk of frailty and mortality.

Broad-band emission of self-trapped exciton in low-dimensional perovskite is prospective for white LED, yet rational design new white perovskite remains challenge. Here, the authors develop an atom-substituting strategy to trigger exciton self-tapping in perovskites and reveal the mechanism behind.

Adult skeletal muscle regeneration is mainly driven by muscle stem cells (MuSCs), which are highly heterogeneous. Here, the authors found that a population of MuSCs, marked by Gli1 expression, is key contributor to muscle regeneration.

In this prespecified analysis of the ongoing TORCHLIGHT phase 3 trial, first-line treatment with toripalimab and nab-paclitaxel in patients with advanced triple-negative breast cancer led to significantly longer progression-free survival in the PD-L1-positive population compared to nab-paclitaxel alone.

Nonalcoholic steatohepatitis (NASH) and associated liver fibrosis have limited therapy options. Here the authors report a novel adiponectin-based dual agonist for adiponectin receptors 1 and 2 with a longer half-life, and show that it ameliorates NASH and liver fibrosis in mouse models.

Yao and Gong et al. identify WD40 repeat-containing protein 6 (WDR6) to be upregulated in the liver of insulin-resistant mice. WDR6 contributes to promoting hepatic de novo lipogenesis during insulin resistance by upregulation of fatty acid synthase, and the authors identify a small molecule to inhibit this effect of WDR6 and reduce hepatic steatosis.

Neurostimulators are often bulky and uncomfortable. Researchers report a wireless, leadless, and battery-free ultrasound receiver that wraps around the target peripheral nerve and allows precise modulation of organ function, providing a framework for future bioelectronic medicines

This Perspective highlights the biofeedback capability of self-sustainable bioelectronics, which provides a new treatment paradigm. This feature enables cells and tissues to autonomously alter the supplied electrical stimulation to meet their varying needs, thereby forming a bidirectional interaction mechanism at organism–machine interfaces.

The membrane-associated RING-CH (MARCH) proteins are E3 ligases regulating stability of plasma membrane (PM) proteins. Here, Liu et al. show that MARCH8 suppresses Influenza A virus infection in vitro and in vivo through redirecting M2 protein from the PM to lysosomes for degradation.

Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.

Gibberellins (GA) negatively regulate UVB-mediated suppression of plant height in plants. Here, the authors show that GmILPA1-mediated degradation of GmGA2ox-like protein counteract the UV-B-mediated reduction of bioactive GAs contributing to the linkage between the affection of UV-B and GA on plant height of soybean.

When and how microglia engulf synapses and myelin is still unclear. Here, the authors provide a suite of flow cytometry-based approaches to quantify engulfment, paving the way for high-throughput assessment of microglial function in health and disease.

The study of main group complexes remains important to our fundamental understanding of main group element bonding and properties. Here the authors isolate and spectroscopically characterize a series of 8-coordinated alkaline earth metal–dinitrogen complexes M(N₂)₈ (M=Ca, Sr, Ba) in a low-temperature neon matrix.

SARS-CoV-2 has spread globally. Here, the authors characterize the entry pathway of SARS-CoV-2, show that the SARS-CoV-2 spike protein is less stable than that of SARS-CoV, and show limited cross-neutralization activities between SARS-CoV and SARS-CoV-2 sera.

MERS-CoV is a novel human coronavirus that has recently caused outbreaks of respiratory illness with high case fatality rate. Here the authors characterize the membrane fusion apparatus of MERS-CoV and develop a peptide that can inhibit virus fusion and replication in vitro.

A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.

Little is known about the genes that confer salt tolerance in trees. Here, Ma et al. report the genome sequence of the desert poplar, Populus euphratica, and provide insight into the genetic architecture and adaptation of this salt tolerant desert poplar.

Designing wereable neural invasive electrical stimulation system remains a challenge. Here, researchers provide an effective technology platform for the elimination of tricky neural stimulus-inertia using bionic electronic modulation, which is a significant step forward for long-lasting treatment of nervous system diseases.

Gene discovery and polygenic predictions from a genome-wide association study of educational attainment in 1.1 million individuals.

Here, the authors exploit a photo-induced barrier-lowering mechanism in MoS₂/ α-MoO_3-x heterojunctions to realize two-dimensional phototransistors with enhanced performance and fast response at low bias voltage.

Solution-phase welding of nanoparticles to form larger structures typically requires that the particles are the same type, limiting the diversity of possible products. Here, the authors report a welding process between gold and chalcogenide nanoparticles in dispersion that leads to asymmetric hybrid nanoparticles with two distinct domains.

The mechanisms by which plant age regulates flowering remain incompletely understood. Here the authors show that age dependent regulation of SPL transcription factors by miR156 influence flowering via control of NF-YB8 expression in Chrysanthemum.

The oncogenic fusion protein AML1-ETO has the ability of AML1 to interact with DNA but blocks AML1-dependent transcription. Here the authors report that histone lysine methyltransferase EZH1 interacts with AML1-ETO and methylates AML1-ETO at lysine 43, promoting AML1-ETO transcriptional repression in leukemia.

Long non-coding RNAs are important regulators of many diverse biological processes. Here the authors describe Linc-RAM, which regulates myogenesis by binding MyoD and promoting the assembly of the MyoD–Baf60c–Brg1 complex at target genes.

A genome-wide association study in ~3 million individuals identifies 3,952 independent variants associated with educational attainment. A polygenic index explains 12–16% of variance for this trait and contributes to risk prediction for ten diseases.