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Quantification of overall tumor burden using longitudinal magnetic resonance imaging improves response assessment in orthotopic murine hepatocellular carcinoma models

Isabella Lurje
Wiebke Werner
Linda Hammerich
ResearchOpen Access05 Feb 2026
Scientific Reports

Volume: 16, P: 1-12
Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity

Strategies to advance T cell based immune therapies are mostly focusing on the improvement of CD8 T cell effector functions, such as cytotoxicity or recruitment to the tumor. Here authors show that by combining in situ vaccination with oncolytic Newcastle Disease Virus and Flt3L-driven dendritic cell expansion, the anti-tumor T cell response is amplified via increased antigen cross-presentation.

Judit Svensson-Arvelund
Sara Cuadrado-Castano
Joshua D. Brody
ResearchOpen Access22 Nov 2022
Nature Communications

Volume: 13, P: 1-18
Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

In situ vaccine recruits and activates cross-presenting dendritic cells and augments PD1 blockade efficacy in patients with indolent non-Hodgkin’s lymphoma.

Linda Hammerich
Thomas U. Marron
Joshua D. Brody
Research08 Apr 2019
Nature Medicine

Volume: 25, P: 814-824
Hepatic inflammatory responses in liver fibrosis

Liver inflammation is a key process that orchestrates intrahepatic injury. This Review offers a comprehensive overview of the inflammatory mechanisms of hepatic fibrosis and discusses current advances and therapeutic implications.

Linda Hammerich
Frank Tacke
Reviews03 Jul 2023
Nature Reviews Gastroenterology & Hepatology

Volume: 20, P: 633-646

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Quantification of overall tumor burden using longitudinal magnetic resonance imaging improves response assessment in orthotopic murine hepatocellular carcinoma models

Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

Hepatic inflammatory responses in liver fibrosis

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