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Showing 1–2 of 2 results
Advanced filters: Author: Linda Truebestein Clear advanced filters

  • Rho kinases regulate the actin cytoskeleton by controlling stress fibre formation. Truebestein et al.show that the length of its coiled-coil determines ROCK2 function, and propose that the coiled coil acts as a spacer, targeting kinase activity to a discrete distance from the membrane.

    • Linda Truebestein
    • Daniel J. Elsner
    • Thomas A. Leonard
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Crystal structures of the protease domain of human HtrA1, with or without its PDZ domain, reveal that this enzyme's activity is controlled by substrate binding to its active site, via an induced-fit mechanism.

    • Linda Truebestein
    • Annette Tennstaedt
    • Michael Ehrmann
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 386-388