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Showing 1–9 of 9 results
Advanced filters: Author: Lindsay Cade Clear advanced filters

  • A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

    • Ken Suzuki
    • Konstantinos Hatzikotoulas
    • Eleftheria Zeggini
    ResearchOpen Access
    Nature
    Volume: 627, P: 347-357

  • Context-dependent assembly (CoDA) of zinc finger nucleases is reported. Starting from an archive of zinc finger modules known to function well together, effective multifinger arrays can be constructed using standard techniques. Also in this issue, Doyon et al. report rational design of nucleases with improved cleavage activity.

    • Jeffry D Sander
    • Elizabeth J Dahlborg
    • J Keith Joung
    Research
    Nature Methods
    Volume: 8, P: 67-69

  • Small molecules identified in two high-throughput screens modulate a strobe-light-induced fear response in zebrafish larvae described as ‘innate freezing’. Some compounds cause escape-like behavior, including several that target the sigma-1 (σ1) receptor.

    • Andrew J Rennekamp
    • Xi-Ping Huang
    • Randall T Peterson
    Research
    Nature Chemical Biology
    Volume: 12, P: 552-558

  • Trever Bivona and colleagues show that the Hippo pathway effector YAP promotes resistance to RAF and MEK inhibitor therapy in multiple types of BRAF-mutant tumors. The findings suggest that combined suppression of YAP and RAF-MEK signaling might enhance treatment response and prevent drug resistance.

    • Luping Lin
    • Amit J Sabnis
    • Trever G Bivona
    Research
    Nature Genetics
    Volume: 47, P: 250-256

  • Gonçalo Abecasis and colleagues report a large-scale meta-analysis of genome-wide association studies for age-related macular degeneration (AMD), including over 17,100 advanced cases and 60,000 controls. They identify seven loci newly associated with AMD and report pathway analysis that shows enrichment in the complement system and atherosclerosis signaling.

    • Lars G Fritsche
    • Wei Chen
    • Gonçalo R Abecasis
    Research
    Nature Genetics
    Volume: 45, P: 433-439

  • This paper reports the genome sequence of domesticated tomato, a major crop plant, and a draft sequence for its closest wild relative; comparative genomics reveal very little divergence between the two genomes but some important differences with the potato genome, another important food crop in the genus Solanum.

    • Shusei Sato
    • Satoshi Tabata
    • René M. Klein Lankhorst
    ResearchOpen Access
    Nature
    Volume: 485, P: 635-641