Human Staufen1 (Stau1) is a double-stranded RNA-binding protein implicated in various post-transcriptional gene-regulatory processes. Genome-wide mapping of Stau1-binding sites, combined with Stau1 knockdown and overexpression analyses, has revealed a new role for Stau1 in regulating translation of GC-rich mRNAs by sensing overall transcript secondary structure.
- Emiliano P Ricci
- Alper Kucukural
- Melissa J Moore
