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Parallel within-host evolution alters virulence factors in an opportunistic Klebsiella pneumoniae during a hospital outbreak

Multidrug-resistant Klebsiella pneumoniae is a critical priority pathogen. Here, the authors explore its evolution in 110 patients during a hospital outbreak, highlighting selected mutation-driven adaptations that alter its key virulence traits.

Greta Zaborskytė
Karin Hjort
Linus Sandegren
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-16
Bacterial gene amplification: implications for the evolution of antibiotic resistance

Gene duplication and amplification can enable bacteria not only to develop antibiotic resistance, but also to overcome the fitness costs that are often associated with resistance. In this Review, Sandegren and Andersson highlight the mechanisms underlying gene duplication and discuss the role of increasing gene copy number in adaptive bacterial evolution.

Linus Sandegren
Dan I. Andersson
Reviews01 Aug 2009
Nature Reviews Microbiology

Volume: 7, P: 578-588
A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes

Danna Lee
Petra Muir
Sanna Koskiniemi
ResearchOpen Access09 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules

Lena K. Nyberg
Saair Quaderi
Fredrik Westerlund
ResearchOpen Access27 Jul 2016
Scientific Reports

Volume: 6, P: 1-10
Genome and plasmid diversity of Extended-Spectrum β-Lactamase-producing Escherichia coli ST131 – tracking phylogenetic trajectories with Bayesian inference

Sofia Ny
Linus Sandegren
Christian G. Giske
ResearchOpen Access16 Jul 2019
Scientific Reports

Volume: 9, P: 1-9
Correction: Corrigendum: Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules

Lena K. Nyberg
Saair Quaderi
Fredrik Westerlund
Amendments and CorrectionsOpen Access22 Dec 2017
Scientific Reports

Volume: 7, P: 1
Strain-level bacterial typing directly from patient samples using optical DNA mapping

Nyblom, Johnning et al. develop an optical DNA mapping approach for bacterial strain typing of patient samples. They demonstrate rapid identification of clinically relevant E. coli and K. pneumoniae strains, without the need for cultivation.

My Nyblom
Anna Johnning
Fredrik Westerlund
ResearchOpen Access23 Feb 2023
Communications Medicine

Volume: 3, P: 1-10
A simple cut and stretch assay to detect antimicrobial resistance genes on bacterial plasmids by single-molecule fluorescence microscopy

Gaurav Goyal
Elina Ekedahl
Fredrik Westerlund
ResearchOpen Access03 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping

Vilhelm Müller
Fredrika Rajer
Fredrik Westerlund
ResearchOpen Access01 Dec 2016
Scientific Reports

Volume: 6, P: 1-11

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Parallel within-host evolution alters virulence factors in an opportunistic Klebsiella pneumoniae during a hospital outbreak

Bacterial gene amplification: implications for the evolution of antibiotic resistance

A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes

Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules

Genome and plasmid diversity of Extended-Spectrum β-Lactamase-producing Escherichia coli ST131 – tracking phylogenetic trajectories with Bayesian inference

Correction: Corrigendum: Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules

Strain-level bacterial typing directly from patient samples using optical DNA mapping

A simple cut and stretch assay to detect antimicrobial resistance genes on bacterial plasmids by single-molecule fluorescence microscopy

Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping

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