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Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

Previous research has suggested that pDCs are required for an effective antiviral immune response, but direct experimental evidence to support this is lacking. Here Ngo et al. develop a pDC knockin mouse model and find that pDCs are dispensable for an antiviral immune response to mouse cytomegalovirus and may be detrimental during influenza or SARS-CoV-2 infection.

Clemence Ngo
Camille Pierini-Malosse
Elena Tomasello
ResearchOpen Access29 Sept 2025
Nature Immunology

P: 1-15
RUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and migration in activated phagocytes

RUFY proteins are known to regulate autophagy, cytoskeletal dynamics, migration and endosomal trafficking. Here, Char et al. show that iRUFY3 plays a role in perinuclear positioning, phagocyte migration and antigen presentation during Salmonella infection.

Rémy Char
Zhuangzhuang Liu
Philippe Pierre
ResearchOpen Access18 Jul 2023
Nature Communications

Volume: 14, P: 1-20
Influence of the transcription factor RORγt on the development of NKp46⁺ cell populations in gut and skin

Mouse lymphoid tissue–inducer (LTi) cells require the transcription factor RORγt. Cupedo's group identifies RORγt⁺ human LTi cell equivalents as committed natural killer cell precursors, and teams led by Vivier and Diefenbach describe RORγt-expressing interleukin 22–producing natural killer cells in mouse gut.

Carmelo Luci
Ana Reynders
Elena Tomasello
Research23 Nov 2008
Nature Immunology

Volume: 10, P: 75-82
Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions

Specialized somatosensory neurons that express Gα_i-interacting protein (GINIP) promote tissue repair in a model of UV-induced skin damage by secreting the neuropeptide TAFA4, which regulates skin-resident macrophages to release IL-10 and limit fibrosis.

Guillaume Hoeffel
Guilhaume Debroas
Sophie Ugolini
Research19 May 2021
Nature

Volume: 594, P: 94-99
Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells

Ugolini and colleagues show that glucocorticoid signaling induces expression of the checkpoint receptor PD-1 on NK cells to control immunopathology in a tissue-specific way.

Linda Quatrini
Elisabeth Wieduwild
Sophie Ugolini
Research20 Aug 2018
Nature Immunology

Volume: 19, P: 954-962

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Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

RUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and migration in activated phagocytes

Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin

Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions

Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells

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Influence of the transcription factor RORγt on the development of NKp46⁺ cell populations in gut and skin