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Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer

A multiomic approach profiles the three-dimensional, epigenetic and mutational landscapes of 80 metastatic prostate cancer biopsies. Hi-C experiments identify an extrachromosomal circular DNA at the AR locus associated with therapy resistance.

Shuang G. Zhao
Matthew Bootsma
Felix Y. Feng
ResearchOpen Access17 Jul 2024
Nature Genetics

Volume: 56, P: 1689-1700
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer

It is hypothesized that there are a number of tumor specific driver genes for metastatic prostate cancer. Here, the authors perform genome-wide CRISPRi screens and integrate these data with metastatic prostate cancer functional and clinical genomics data to show that KIF4A and WDR62 drive aggressive prostate cancer phenotypes.

Rajdeep Das
Martin Sjöström
Luke A. Gilbert
ResearchOpen Access29 Jul 2021
Nature Communications

Volume: 12, P: 1-12
The DNA methylation landscape of advanced prostate cancer

Whole-genome bisulfite sequencing along with whole-genome and transcriptome sequencing of 100 prostate cancer metastases identifies genomic regions that are differentially methylated during disease progression and a novel epigenomic subtype.

Shuang G. Zhao
William S. Chen
Felix Y. Feng
Research13 Jul 2020
Nature Genetics

Volume: 52, P: 778-789

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