The mitochondrial genome is of maternal origin and mutations in mitochondrial DNA are the cause of many human diseases. The efficient replacement of the mitochondrial genome in mature non-human primate oocytes is now demonstrated. This approach may offer a reproductive option to prevent the transmission of diseases caused by mutations in mitochondrial DNA in affected families.
- Masahito Tachibana
- Michelle Sparman
- Shoukhrat Mitalipov
