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Showing 1–5 of 5 results
Advanced filters: Author: Lisa Durocher Clear advanced filters

  • Determinants of WEE1 inhibitor sensitivity in cancer cells are largely undefined. Here, the authors show that WEE1 inhibitors beyond their cell cycle perturbing effects also lead to paradoxical activation of the integrated stress response kinase GCN2.

    • Rinskje B. Tjeerdsma
    • Timothy F. Ng
    • Marcel A.T.M. van Vugt
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Macrophages survey their surroundings using macropinocytosis, but its regulation is unclear. Here, the authors report that SLIT2, a known inhibitor of Rac GTPases, is an endogenous inhibitor of macropinocytosis, and that SLIT2 limits the uptake of NOD2 ligands into immune cells and subsequent release of the inflammatory chemokine, CXCL1, in vivo.

    • Vikrant K. Bhosle
    • Tapas Mukherjee
    • Lisa A. Robinson
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Two classes of enzyme — cyclin-dependent kinases (CDK) and Dbf4-dependent kinase (DDK) — facilitate the initiation of DNA replication in eukaryotes. It is now shown that, when DNA damage is sensed, another kinase, Rad53, halts the firing of late replication origins by inhibiting both the CDK and the DDK pathways. Rad53 acts on DDK directly by inhibiting Dbf4, whereas the CDK pathway is blocked by Rad53-mediated phosphorylation of the downstream CDK substrate Sld3.

    • Jaime Lopez-Mosqueda
    • Nancy L. Maas
    • David P. Toczyski
    Research
    Nature
    Volume: 467, P: 479-483